Caspase 4, apoptosis-related cysteine protease (Trembl v27)

Vertebrate gene cluster 1993189. 20 members

Hsa	Mmu	Rno	Cfa	Mdo	Gga	Xtr	Gac	Ola	Tru	Dre
1	2	2	2	3	1	1	1	1	3	3

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KOG Class:

METABOLISM [ D ] : Cell cycle control, cell division, chromosome partitioning

Genes in this cluster
Functional Analysis
Multiple Sequence Alignment

Org	Chrom	DbXref	Symbol	Defline	Domains Synteny
Hsa	11	ENSP00000260309 CASP1_HUMAN [ST] 834 [EG] CASP1 [HU] Hs.2490 [UG] NP_150634 [RS] Q53EY6 [ST] P29466 [ST] Q6DMQ1 [ST] X65019 [EM] M87507 [EM] U13697 [EM] U13698 [EM] U13699 [EM] U13700 [EM] AK223503 [EM] AY660536 [EM]	CASP1(HGNCID) U13698 U13700 U13699 U13697 M87507 X65019 AY660536 AK223503 NM_033292 ENSG00000137752 ENST00000260309	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) ... (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit] . [Source:Uniprot/SWISSPROT; Acc:	PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (163 - 400) 404 closeENSP00000328409 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSP00000304713 is a member of Cluster 1992896: KIAA1826 (KIAA1826), mRNA [Source:RefSeq_dna;Acc:NM_032424] closeENSP00000282499 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSP00000236886 is a member of Cluster 1989856: CARD only protein (Trembl v5) closeENSP00000364858 is a member of Cluster 1989856: CARD only protein (Trembl v5) closeENSP00000260309 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSP00000260315 is a member of Cluster 2049587: Caspase-5 precursor (EC 3.4.22.-) (CASP-5) (ICH-3 protease) (TY protea... closeENSP00000347741 is a member of Cluster 2074525: Caspase-4 precursor (EC 3.4.22.-) (CASP-4) (ICH-2 protease) (TX protea... closeENSP00000364878 is a member of Cluster 2060018: CASP12P1. [Source:Uniprot/SPTREMBL;Acc:Q6UXS9] closeENSP00000302805 is a member of Cluster 1997220: DDI1, DNA-damage inducible 1, homolog 1 [Source:RefSeq_peptide;Acc:NP_... closeENSP00000302193 is a member of Cluster 1996524: Pdgfd protein (Trembl v25)
Mmu	9	ENSMUSP00000027015 12362 [EG] L03799 [EM] L28095 [EM] U04269 [EM] BC008152 [EM] Mm.1051 [UG] NP_033937 [RS] CASP1_MOUSE [ST] P29452 [ST]	Casp1 NM_009807 ENSMUST00000027015 ENSMUSG00000025888	caspase 1 [Source:MarkerSymbol; Acc:MGI:96544]	PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (162 - 398) 402 closeENSMUSP00000053971 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl trans... closeENSMUSP00000050183 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSMUSP00000038267 is a member of Cluster 1992895: RIKEN cDNA 8430410K20 gene (8430410K20Rik), mRNA [Source:RefSeq_dna;Ac... closeENSMUSP00000066980 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSMUSP00000096630 is a member of Cluster 2037501: RNA for type IIB intracisternal A-particle (IAP) element encoding inte... closeENSMUSP00000027015 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMUSP00000027012 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMUSP00000027009 is a member of Cluster 2066632: caspase 12 [Source:MarkerSymbol;Acc:MGI:1312922] closeENSMUSP00000056240 is a member of Cluster 1996524: Pdgfd protein (Trembl v25) closeENSMUSP00000053223 is a member of Cluster 1997218: PREDICTED: similar to DNA-damage inducible protein 2 [Source:RefSeq_pe... closeENSMUSP00000096629 is a member of Cluster 2035567: Translation initiation factor 1 (eIF-1/SUI1)
Mmu	9	ENSMUSP00000027012 12363 [EG] AK171877 [EM] AK151547 [EM] BC061255 [EM] U59463 [EM] Y13089 [EM] Mm.1569 [UG] NP_031635 [RS] CASP4_MOUSE [ST] Q3TAF3 [ST] P70343 [ST] Q6P8H1 [ST]	Casp4 NM_007609 ENSMUST00000027012 ENSMUSG00000033538	caspase 4, apoptosis-related cysteine peptidase ... [Source:MarkerSymbol; Acc:MGI:107700]	PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (132 - 369) 373 closeENSMUSP00000050183 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSMUSP00000038267 is a member of Cluster 1992895: RIKEN cDNA 8430410K20 gene (8430410K20Rik), mRNA [Source:RefSeq_dna;Ac... closeENSMUSP00000066980 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSMUSP00000096630 is a member of Cluster 2037501: RNA for type IIB intracisternal A-particle (IAP) element encoding inte... closeENSMUSP00000027015 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMUSP00000027012 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMUSP00000027009 is a member of Cluster 2066632: caspase 12 [Source:MarkerSymbol;Acc:MGI:1312922] closeENSMUSP00000056240 is a member of Cluster 1996524: Pdgfd protein (Trembl v25) closeENSMUSP00000053223 is a member of Cluster 1997218: PREDICTED: similar to DNA-damage inducible protein 2 [Source:RefSeq_pe... closeENSMUSP00000096629 is a member of Cluster 2035567: Translation initiation factor 1 (eIF-1/SUI1) closeENSMUSP00000046733 is a member of Cluster 1975181: DYNC2H1 protein (Trembl v3)
Rno	8	ENSRNOP00000009993 25166 [EG] U14647 [EM] U34621 [EM] S79676 [EM] D85899 [EM] Rn.37508 [UG] NP_036894 [RS] CASP1_RAT [ST] Q91W32 [ST] P43527 [ST]	Casp1 NM_012762 ENSRNOT00000009993 ENSRNOG00000007372	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) ... (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit] . [Source:Uniprot/SWISSPROT; Acc:	PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (162 - 398) 402 closeENSRNOP00000008062 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl trans... closeENSRNOP00000035320 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSRNOP00000050475 is a member of Cluster 2050518: uncharacterized closeENSRNOP00000030251 is a member of Cluster 1992887: uncharacterized closeENSRNOP00000009542 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSRNOP00000009993 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSRNOP00000058685 is a member of Cluster 2076952: caspase 11 [Source:RefSeq_peptide;Acc:NP_446188] closeENSRNOP00000029448 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSRNOP00000058681 is a member of Cluster 2012484: uncharacterized closeENSRNOP00000058680 is a member of Cluster 2012484: uncharacterized closeENSRNOP00000048876 is a member of Cluster 2004411: RNA polymerase II transcription elongation factor Elongin/SIII, subuni...
Rno	8	ENSRNOP00000029448	ENSRNOG00000033434 ENSRNOT00000037317	caspase 12 [Source:RefSeq_peptide; Acc:NP_569106] ...	PF00619: Caspase recruitment domain (4 - 91) PF00656: Caspase domain (178 - 417) 421 closeENSRNOP00000050475 is a member of Cluster 2050518: uncharacterized closeENSRNOP00000030251 is a member of Cluster 1992887: uncharacterized closeENSRNOP00000009542 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSRNOP00000009993 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSRNOP00000058685 is a member of Cluster 2076952: caspase 11 [Source:RefSeq_peptide;Acc:NP_446188] closeENSRNOP00000029448 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSRNOP00000058681 is a member of Cluster 2012484: uncharacterized closeENSRNOP00000058680 is a member of Cluster 2012484: uncharacterized closeENSRNOP00000048876 is a member of Cluster 2004411: RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin B closeENSRNOP00000039308 is a member of Cluster 1996524: Pdgfd protein (Trembl v25) closeENSRNOP00000037523 is a member of Cluster 1997219: PREDICTED: similar to DNA-damage inducible protein 1 [Source:RefSeq_peptide_predicted;Acc:XP_345896]
Cfa	NW_876312	NP_001003125.1			PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (163 - 400) 405 closeXP_854438.1 is a member of Cluster 2005218: uncharacterized closeXP_546544.2 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase closeXP_536591.2 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeXP_862908.1 is a member of Cluster 1992892: uncharacterized closeXP_863051.1 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeNP_001003125.1 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeXP_536593.2 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeXP_536594.2 is a member of Cluster 2001424: Multifunctional chaperone (14-3-3 family) closeXP_854523.1 is a member of Cluster 1997228: DNA damage inducible protein closeXP_536595.2 is a member of Cluster 1996524: Pdgfd protein (Trembl v25) closeXP_863187.1 is a member of Cluster 1975181: DYNC2H1 protein (Trembl v3)
Cfa	NW_876312	XP_536593.2			PF00656: Caspase domain (307 - 545) 550 closeXP_546544.2 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase closeXP_536591.2 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeXP_862908.1 is a member of Cluster 1992892: uncharacterized closeXP_863051.1 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeNP_001003125.1 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeXP_536593.2 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeXP_536594.2 is a member of Cluster 2001424: Multifunctional chaperone (14-3-3 family) closeXP_854523.1 is a member of Cluster 1997228: DNA damage inducible protein closeXP_536595.2 is a member of Cluster 1996524: Pdgfd protein (Trembl v25) closeXP_863187.1 is a member of Cluster 1975181: DYNC2H1 protein (Trembl v3) closeXP_536597.1 is a member of Cluster 2028320: Porin/voltage-dependent anion-selective channel protein
Mdo	4	ENSMODP00000034033	ENSMODG00000014762 ENSMODT00000035619		PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (162 - 399) 403 closeENSMODP00000034050 is a member of Cluster 1982180: Coiled-coil-helix-coiled-coil-helix domain containing 4 (Predicted) (Trembl v6) closeENSMODP00000018414 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase closeENSMODP00000018416 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSMODP00000018418 is a member of Cluster 1992897: uncharacterized closeENSMODP00000034036 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSMODP00000034033 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034022 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034020 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034018 is a member of Cluster 2021859: Hypothetical protein FLJ42984 (Trembl v27) closeENSMODP00000000011 is a member of Cluster 2041759: uncharacterized closeENSMODP00000034014 is a member of Cluster 2071090: DNA-binding centromere protein B (CENP-B)
Mdo	4	ENSMODP00000034022	ENSMODG00000014752 ENSMODT00000035608		PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (164 - 401) 405 closeENSMODP00000018414 is a member of Cluster 2008147: Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase closeENSMODP00000018416 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSMODP00000018418 is a member of Cluster 1992897: uncharacterized closeENSMODP00000034036 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSMODP00000034033 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034022 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034020 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034018 is a member of Cluster 2021859: Hypothetical protein FLJ42984 (Trembl v27) closeENSMODP00000000011 is a member of Cluster 2041759: uncharacterized closeENSMODP00000034014 is a member of Cluster 2071090: DNA-binding centromere protein B (CENP-B) closeENSMODP00000000105 is a member of Cluster 1997293: Uncharacterized conserved protein
Mdo	4	ENSMODP00000034020	ENSMODG00000024417 ENSMODT00000035606		PF00656: Caspase domain (44 - 280) 284 closeENSMODP00000018416 is a member of Cluster 2011554: Hypothetical protein (Fragment) (Trembl v3) closeENSMODP00000018418 is a member of Cluster 1992897: uncharacterized closeENSMODP00000034036 is a member of Cluster 1982677: Glutamate receptor, ionotropic, AMPA4 (Alpha 4) (Trembl v27) closeENSMODP00000034033 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034022 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034020 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSMODP00000034018 is a member of Cluster 2021859: Hypothetical protein FLJ42984 (Trembl v27) closeENSMODP00000000011 is a member of Cluster 2041759: uncharacterized closeENSMODP00000034014 is a member of Cluster 2071090: DNA-binding centromere protein B (CENP-B) closeENSMODP00000000105 is a member of Cluster 1997293: Uncharacterized conserved protein closeENSMODP00000000110 is a member of Cluster 2009907: Mus musculus 13 days embryo forelimb cDNA, RIKEN full-length enriched library, clone:5930431H10 product:hypothetical Signal peptidase containing protein, full insert sequence (Trembl v26)
Gga	19	ENSGALP00000001569 NP_990255 [RS] 395764 [EG] AF031351 [EM] O42284 [ST]	ENSGALG00000001049 ENSGALT00000001571	caspase 1, apoptosis-related cysteine protease ... (interleukin 1, beta, convertase) [Source:RefSeq_peptide; Acc:NP_990255]	PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (180 - 417) 421 closeENSGALP00000001392 is a member of Cluster 2027701: Transcription initiation protein SPT4 homolog 1 (SwissProt v46) closeENSGALP00000001522 is a member of Cluster 2008328: ring finger protein 43 [Source:RefSeq_peptide;Acc:NP_060233] [from human gene ENSG00000108375] closeENSGALP00000034538 is a member of Cluster 1973145: Hypothetical protein FLJ40311 (Trembl v22) closeENSGALP00000001554 is a member of Cluster 1982650: Myotubularin related protein 4 (Trembl v26) closeENSGALP00000034530 is a member of Cluster 2008262: uncharacterized closeENSGALP00000001569 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSGALP00000001581 is a member of Cluster 1991206: Predicted alpha/beta hydrolase closeENSGALP00000001584 is a member of Cluster 1976452: Claudin-9. [Source:Uniprot/SWISSPROT;Acc:O95484] [from human gene ENSG00000178709] closeENSGALP00000001601 is a member of Cluster 1980231: Elastin precursor (Tropoelastin) (Fragment). [Source:Uniprot/SWISSPROT;Acc:P07916] closeENSGALP00000001609 is a member of Cluster 1986516: Activated spleen cDNA, RIKEN full-length enriched library, clone:F830035G07 product:LIM-domain containing, protein kinase, full insert sequence. (Fragment) (Trembl v7) closeENSGALP00000001639 is a member of Cluster 2051549: uncharacterized
Xtr	scaffold_135	337028	casp1	caspase 1, apoptosis-related cysteine peptidase ... (interleukin 1, beta, convertase)	PF00619: Caspase recruitment domain (2 - 89) PF00656: Caspase domain (144 - 380) 385 close166403 is a member of Cluster 2008329: Predicted E3 ubiquitin ligase close55263 is a member of Cluster 1973145: Hypothetical protein FLJ40311 (Trembl v22) close336998 is a member of Cluster 1995005: 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4HPPD) (HPD) (HPPDase) (4-hydroxyphenylpyruvic acide oxidase) (SwissProt v51) close273825 is a member of Cluster 1989856: CARD only protein (Trembl v5) close336996 is a member of Cluster 1982650: Myotubularin related protein 4 (Trembl v26) close337028 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) close166409 is a member of Cluster 1991206: Predicted alpha/beta hydrolase close166410 is a member of Cluster 2076057: uncharacterized close293209 is a member of Cluster 1976464: uncharacterized close25749 is a member of Cluster 2038167: uncharacterized close293210 is a member of Cluster 1976411: uncharacterized
Gac	groupI	ENSGACP00000013201	ENSGACG00000009989 ENSGACT00000013226		PF00619: Caspase recruitment domain (3 - 90) PF00656: Caspase domain (137 - 372) 376 closeENSGACP00000013332 is a member of Cluster 2010805: ADP-ribosylation factor 7 (Trembl v29) closeENSGACP00000013327 is a member of Cluster 1980638: Protein phosphatase 2C isoform epsilon (EC 3.1.3.16) (PP2C-epsilon) (Protein phosphatase 1L) (Protein phosphatase 1-like) (SwissProt v13) closeENSGACP00000013321 is a member of Cluster 1991024: CGI-07 protein (Trembl v26) closeENSGACP00000013227 is a member of Cluster 2014502: FcRIb protein (Trembl v27) closeENSGACP00000013219 is a member of Cluster 1976934: RAB guanine nucleotide exchange factor (GEF) 1 (Trembl v27) closeENSGACP00000013201 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSGACP00000013187 is a member of Cluster 1983584: SNARE protein Syntaxin 1 and related proteins closeENSGACP00000013145 is a member of Cluster 1989752: Predicted protein carboxyl methylase closeENSGACP00000013138 is a member of Cluster 1973815: uncharacterized closeENSGACP00000013135 is a member of Cluster 1983899: SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains) (SwissProt v46) closeENSGACP00000013126 is a member of Cluster 2010621: uncharacterized
Ola	13	ENSORLP00000007938 Ola.10294 [UG]	ENSORLG00000006320 ENSORLT00000007939		PF00619: Caspase recruitment domain (1 - 62) PF00656: Caspase domain (109 - 352) 362 closeENSORLP00000007854 is a member of Cluster 2069679: uncharacterized closeENSORLP00000007886 is a member of Cluster 1991024: CGI-07 protein (Trembl v26) closeENSORLP00000007892 is a member of Cluster 1980120: Collagens (type IV and type XIII), and related proteins closeENSORLP00000007897 is a member of Cluster 2014502: FcRIb protein (Trembl v27) closeENSORLP00000007918 is a member of Cluster 1976934: RAB guanine nucleotide exchange factor (GEF) 1 (Trembl v27) closeENSORLP00000007938 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSORLP00000007951 is a member of Cluster 1983584: SNARE protein Syntaxin 1 and related proteins closeENSORLP00000007989 is a member of Cluster 1989752: Predicted protein carboxyl methylase closeENSORLP00000007995 is a member of Cluster 1973815: uncharacterized closeENSORLP00000008025 is a member of Cluster 1983899: SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains) (SwissProt v46) closeENSORLP00000008044 is a member of Cluster 2010617: CASP protein (Fragment) (Trembl v26)
Tru	scaffold_9	594273			PF00656: Caspase domain (1 - 223) 229 close594162 is a member of Cluster 1986856: uncharacterized close594602 is a member of Cluster 1980120: Collagens (type IV and type XIII), and related proteins close594430 is a member of Cluster 2014502: FcRIb protein (Trembl v27) close594539 is a member of Cluster 1976934: RAB guanine nucleotide exchange factor (GEF) 1 (Trembl v27) close594555 is a member of Cluster 1989856: CARD only protein (Trembl v5) close594273 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) close708387 is a member of Cluster 1973795: Ribonucleotide reductase M1 (Trembl v27) close594270 is a member of Cluster 1996472: Glutaminyl cyclase close135288 is a member of Cluster 2048387: uncharacterized close594382 is a member of Cluster 2000579: Interleukin-12 p35 subunit (Fragment) (Trembl v27) close594354 is a member of Cluster 2009486: uncharacterized
Tru	scaffold_9	751843			PF00619: Caspase recruitment domain (2 - 89) PF00656: Caspase domain (136 - 379) 385 close594423 is a member of Cluster 1975398: Predicted E3 ubiquitin ligase close751841 is a member of Cluster 1983265: Bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830086J02 product:SMC4 structural maintenance of chromosomes 4- like 1 (yeast), full insert sequence. (Fragment) (Trembl v5) close708394 is a member of Cluster 2031422: Hypothetical protein DKFZp434A2115 (Fragment) (Trembl v26) close594348 is a member of Cluster 2008152: uncharacterized close720044 is a member of Cluster 2029166: uncharacterized close751843 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) close594302 is a member of Cluster 2021023: SNARE protein Syntaxin 1 and related proteins close708396 is a member of Cluster 1989752: Predicted protein carboxyl methylase close186337 is a member of Cluster 1973815: uncharacterized close594558 is a member of Cluster 1983899: SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains) (SwissProt v46) close594356 is a member of Cluster 2010619: uncharacterized
Tru	scaffold_4498	746928			PF00619: Caspase recruitment domain (2 - 89) PF00656: Caspase domain (136 - 377) 383 close746928 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27)
Dre	1	ENSDARP00000059407 566185 [EG]	ENSDARG00000052040 ENSDART00000059408		PF00656: Caspase domain (15 - 248) 252 closeENSDARP00000036819 is a member of Cluster 1979668: Mannosyltransferase closeENSDARP00000068286 is a member of Cluster 2050922: aryl-hydrocarbon receptor repressor a [Source:RefSeq_peptide;Acc:NP_001030342] closeENSDARP00000003071 is a member of Cluster 1975770: Predicted NUDIX hydrolase FGF-2 and related proteins closeENSDARP00000046128 is a member of Cluster 2000908: Hypothetical protein zgc:64172 (Trembl v26) closeENSDARP00000068269 is a member of Cluster 2000908: Hypothetical protein zgc:64172 (Trembl v26) closeENSDARP00000059407 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSDARP00000068268 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSDARP00000068267 is a member of Cluster 2040836: hypothetical protein LOC553197 [Source:RefSeq_peptide;Acc:NP_001018156] closeENSDARP00000075565 is a member of Cluster 1973449: GLT25D1 protein (Trembl v26) closeENSDARP00000068266 is a member of Cluster 1979268: Thioredoxin, nucleoredoxin and related proteins closeENSDARP00000056225 is a member of Cluster 1987552: uncharacterized
Dre	1	ENSDARP00000068268 259303 [EG] DQ022755 [EM] AF327410 [EM] BC095000 [EM] Dr.10735 [UG] Q4U0E2 [ST] NP_690840 [RS] Q9DDJ2 [ST] Q504J1 [ST]	caspb NM_152884 ZDB-GENE-020812-1 ENSDART00000073778 ENSDARG00000052039	caspase b [Source:RefSeq_peptide; Acc:NP_690840]	PF02758: PAAD/DAPIN/Pyrin domain (4 - 85) PF00656: Caspase domain (176 - 402) 406 closeENSDARP00000068286 is a member of Cluster 2050922: aryl-hydrocarbon receptor repressor a [Source:RefSeq_peptide;Acc:NP_001030342] closeENSDARP00000003071 is a member of Cluster 1975770: Predicted NUDIX hydrolase FGF-2 and related proteins closeENSDARP00000046128 is a member of Cluster 2000908: Hypothetical protein zgc:64172 (Trembl v26) closeENSDARP00000068269 is a member of Cluster 2000908: Hypothetical protein zgc:64172 (Trembl v26) closeENSDARP00000059407 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSDARP00000068268 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSDARP00000068267 is a member of Cluster 2040836: hypothetical protein LOC553197 [Source:RefSeq_peptide;Acc:NP_001018156] closeENSDARP00000075565 is a member of Cluster 1973449: GLT25D1 protein (Trembl v26) closeENSDARP00000068266 is a member of Cluster 1979268: Thioredoxin, nucleoredoxin and related proteins closeENSDARP00000056225 is a member of Cluster 1987552: uncharacterized closeENSDARP00000016852 is a member of Cluster 1991324: uncharacterized
Dre	16	ENSDARP00000034228 57933 [EG] AF233434 [EM] BC095022 [EM] Dr.1168 [UG] Q9I9L7 [ST] NP_571580 [RS]	caspa NM_131505 ZDB-GENE-000616-3 ENSDART00000034544 ENSDARG00000008165	caspase a [Source:RefSeq_peptide; Acc:NP_571580]	PF02758: PAAD/DAPIN/Pyrin domain (5 - 85) PF00656: Caspase domain (147 - 381) 385 closeENSDARP00000070509 is a member of Cluster 2014947: fibrillarin [Source:RefSeq_peptide;Acc:NP_998167] closeENSDARP00000030868 is a member of Cluster 1983430: Dual-specificity tyrosine-phosphorylation regulated kinase closeENSDARP00000058619 is a member of Cluster 2019623: hypothetical protein LOC327616 [Source:RefSeq_peptide;Acc:NP_956132] closeENSDARP00000058612 is a member of Cluster 1973645: Mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830016K02 product:E26 avian leukemia oncogene 2, 3' domain, full insert sequence (Trembl v7) closeENSDARP00000045402 is a member of Cluster 1973645: Mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830016K02 product:E26 avian leukemia oncogene 2, 3' domain, full insert sequence (Trembl v7) closeENSDARP00000034228 is a member of Cluster 1993189: Caspase 4, apoptosis-related cysteine protease (Trembl v27) closeENSDARP00000055920 is a member of Cluster 1986089: Apoptosis-associated speck-like protein (Trembl v24) closeENSDARP00000079066 is a member of Cluster 1994726: Sodium channel, voltage-gated, type I, beta (Trembl v10) closeENSDARP00000034904 is a member of Cluster 1987451: Proteasome 26S ATPase subunit 4 (Trembl v12) closeENSDARP00000007253 is a member of Cluster 1994092: Beta-1,4-galactosyltransferase 3 (EC 2.4.1.-) (Beta-1,4-GalTase 3) (Beta4Gal-T3) (b4Gal-T3) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 3) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 3) [Includes: N-acetyllactosamine s closeENSDARP00000070367 is a member of Cluster 2006245: Socius (SOC) (Trembl v29)

ID	Type	Description	Hsa	Mmu	Rno	Cfa	Mdo	Gga	Xtr	Gac	Ola	Tru	Dre	Oth
PTHR10454:SF15	PANTHER	CASPASE-9	-	1	-	-	-	-	-	-	-	-	-	x
PTHR10454:SF14	PANTHER	CYSTEINE PROTEASE-RELATED	-	-	-	ALL	1	-	-	-	-	-	-	x
PTHR10454:SF13	PANTHER	CASPASE-10	ALL	1	1	-	2	ALL	-	-	-	-	-	x
PTHR10454:SF12	PANTHER	CASPASE-RELATED	-	-	1	-	-	-	-	-	-	-	-	x
PTHR10454:SF11	PANTHER	CASPASE-RELATED	-	-	-	-	-	-	ALL	-	-	-	-	x
PTHR10454:SF10	PANTHER	CASPASE RELATED	-	-	-	-	-	-	-	ALL	ALL	ALL	ALL	x
PF02758	PFAM	PAAD/DAPIN/Pyrin domain	-	-	-	-	-	-	-	-	-	-	2	x
PF00656	PFAM	Caspase domain	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	x
PF00619	PFAM	Caspase recruitment domain	ALL	ALL	ALL	1	2	ALL	ALL	ALL	ALL	2	-	x
KOG3573	KOG	Caspase, apoptotic cysteine protease	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	2	ALL	x
K04741	KEGGORTH	CASP12; caspase 12, apoptosis-related cysteine protease [EC:3.4.22.- ]	-	-	1	-	-	-	-	-	-	-	-	x
K04394	KEGGORTH	CASP4; caspase 4, apoptosis-related cysteine protease [EC:3.4.22.- ]	-	1	-	-	-	-	-	-	-	-	-	x
K01370	KEGGORTH	CASP1; caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) [EC:3.4.22.36 ]	ALL	1	1	-	-	-	-	-	-	1	-	x
GO:0043123	GO	positive regulation of I-kappaB kinase/NF-kappaB cascade	ALL	1	-	-	-	-	-	-	-	-	-	x
GO:0042981	GO	regulation of apoptosis	ALL	ALL	1	-	-	-	-	-	-	-	-	x
GO:0030693	GO	caspase activity	ALL	ALL	1	-	-	ALL	-	-	-	-	2	x
GO:0016787	GO	hydrolase activity	-	-	-	-	-	-	-	-	-	-	2	x
GO:0016485	GO	protein processing	-	1	1	-	-	-	-	-	-	-	-	x
GO:0008656	GO	caspase activator activity	ALL	1	-	-	-	-	-	-	-	-	-	x
GO:0008234	GO	cysteine-type peptidase activity	ALL	ALL	1	-	-	-	-	-	-	-	2	x
GO:0008233	GO	peptidase activity	-	-	-	-	-	-	-	-	-	-	2	x
GO:0007165	GO	signal transduction	ALL	1	-	-	-	-	-	-	-	-	-	x
GO:0006917	GO	induction of apoptosis	-	ALL	ALL	-	-	-	-	-	-	-	-	x
GO:0006508	GO	proteolysis and peptidolysis	ALL	ALL	1	-	-	ALL	-	-	-	-	2	x
GO:0005783	GO	endoplasmic reticulum	-	-	1	-	-	-	-	-	-	-	-	x
GO:0005737	GO	cytoplasm	-	1	1	-	-	-	-	-	-	-	-	x
GO:0005622	GO	intracellular	ALL	1	1	-	-	-	-	-	-	-	-	x
GO:0005576	GO	extracellular	-	1	1	-	-	-	-	-	-	-	-	x
GO:0005515	GO	protein binding	ALL	ALL	1	-	-	-	-	-	-	-	-	x
GO:0004871	GO	signal transducer activity	ALL	1	-	-	-	-	-	-	-	-	-	x
GO:0001666	GO	response to hypoxia	-	1	1	-	-	-	-	-	-	-	-	x
3.4.22.36	EC	Caspase-1.	ALL	1	1	-	-	-	-	-	-	-	-	x
3.4.22.-	EC	Cysteine endopeptidases.	-	1	1	-	-	-	-	-	-	-	-	x

Caspase 4, apoptosis-related cysteine protease (Trembl v27)

KOG Class:

Cluster gene display:

Species visible: