Skip to content
Metazome release 2.0.4 24 metazoan proteomes 9 ancestral nodes DOE JGI and University of California
Metazome

Metazome release 2.0.4

Trace metazoan genes through nine ancestral nodes.

Metazome organizes the proteomes of twenty four metazoans into gene families defined at nine ancestral nodes on the metazoan evolutionary tree. Search by gene symbol, identifier, defline, or PFAM and PANTHER domain content, or use BLAST to place a sequence from another organism in the most appropriate gene family.

Find a gene family BLAST a sequence Read the clustering method
24
metazoan proteomes
9
ancestral nodes
2.0.4
current release
Clade explorer Select a node to inspect its families

Teleost

Gene families representing the most recent common ancestor of euteleostei and otocephala.

Gene families
16,213
Singletons
33,235

Largest family
26 members, Glicacolin related and C1q domain containing protein

Includes
4 genomes

Open node recordSearch this node

Metazome tools

01 / Search

Keyword search

Search gene symbols, identifiers, deflines, and ontology terms across the release index.

 02 / Sequence

BLAST

Prepare a sequence search against a single genome or an ancestral node consensus set.

 03 / Genomes

Genome register

Browse assembly sources, clade paths, and record pages for all twenty four proteomes.

01 / Genomes

Twenty four metazoan proteomes

Filter by scientific name, common name, group, or code. Each record opens a page with its assembly source, clade path, and related nodes.

24 genomes
No genome matches that filter. Try a scientific name, common name, group, or code.

02 / Method

A hierarchical view of gene family evolution.

Clustering from crown to root

Gene families are built hierarchically, first by paralog clustering within a branch and then by ortholog merging across branches. Every gene belongs to one cluster at each node. Read the method.

Nine ancestral nodes

Each node represents an ancestral gene set at a significant point in metazoan evolution.

EumetazoaBilateriaProtostomeDeuterostomeArthropodChordateVertebrateTeleostTetrapod

Annotation layer

Where possible, genes carry PFAM, KOG, KEGG, and PANTHER assignments, with public annotations from RefSeq, UniProt, Ensembl, and JGI. Data sources.

03 / Updates

Release notes and site history

The Metazome interface, genome set, and cluster tools have changed across releases. The record below preserves the updates that shaped version 2.0.4.

All news and release notes
  • 11/12/2023

    Composite cluster capability added to Metazome

    Metazome v2.0.3 added the ability to combine single node keyword or BLAST results into a composite cluster for viewing on a cluster summary page.

  • 10/23/2023

    Metazome genomes updated and expanded

    The release includes updated Ensembl v41 genomes of twelve species and fourteen additional genomes, bringing the total to twenty four clustered proteomes.

  • 10/23/2023

    New website

    A complete rework of the Metazome website simplified navigation, enhanced synteny viewing, added customizable cluster displays, and expanded help documentation.

  • 01/08/2008

    Minor update to the Metazome interface

    The Click Info panel was removed from the Cluster Summary page. Syntenic gene cluster and PFAM domain information now appears in pop up boxes.

04 / Project

A joint project of the U.S. Department of Energy and the University of California.

Metazome supports comparative genomic studies among metazoans. The project is maintained as a reference resource for gene family evolution across twenty four sequenced and annotated proteomes, with clustering at nine ancestral nodes.

About the project, team, and data sources

Sister project

Phytozome

Phytozome applies the same comparative framework to land plant proteomes, with clustering at six ancestral nodes.

Read the Phytozome record